Conservation denotes the percentage of residues that match that of the rCRS among selected species. A query variant is depicted in isolation (i.e., other variants in a test sequence are not shown) and is flanked by rCRS reference for clarity.
| Species | -5 | -4 | -3 | -2 | -1 | 0 | +1 | +2 | +3 | +4 | +5 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Variant at rCRS pos 3635 (locus pos 110) of ND1 | I | L | A | T | S | N | L | A | V | Y | S |
| Homo sapiens (rCRS) | I | L | A | T | S | S | L | A | V | Y | S |
| Alligator mississippiensis | L | L | A | M | S | S | L | M | V | Y | S |
| Artibeus jamaicensis | M | L | A | M | S | S | L | A | V | Y | S |
| Balaenoptera musculus | M | L | A | M | S | S | L | A | V | Y | S |
| Balaenoptera physalus | M | L | A | M | S | S | L | A | V | Y | S |
| Bos taurus | M | L | A | M | S | S | L | A | V | Y | S |
| Canis lupus familiaris | M | L | A | M | S | S | L | A | V | Y | S |
| Cebus albifrons | M | L | A | T | S | S | L | A | V | Y | S |
| Ceratotherium simum | M | L | A | M | S | S | L | A | V | Y | S |
| Cyprinus carpio | I | L | A | L | S | S | L | A | V | Y | S |
| Dasypus novemcinctus | I | L | A | M | S | S | L | A | V | Y | S |
| Didelphis virginiana | I | L | A | L | S | G | L | S | V | Y | S |
| Drosophila melanogaster | F | L | C | C | T | S | L | G | V | Y | T |
| Equus asinus | M | L | A | M | S | S | L | A | V | Y | S |
| Equus caballus | M | L | A | M | S | S | L | A | V | Y | S |
| Erinaceus europaeus | I | L | A | L | S | S | L | A | V | Y | S |
| Felis catus | M | L | A | M | S | S | L | A | V | Y | S |
| Gallus gallus | L | L | A | M | S | S | L | T | V | Y | S |
| Glis glis | I | L | A | T | S | S | L | A | V | H | S |
| Gorilla gorilla | I | L | A | T | S | S | L | A | V | Y | S |
| Halichoerus grypus | M | L | A | M | S | S | L | A | V | Y | S |
| Hippopotamus amphibius | M | L | A | M | S | S | L | A | V | Y | S |
| Hylobates lar | I | L | A | T | S | S | L | T | V | Y | S |
| Loxodonta africana | I | L | A | M | S | S | L | M | V | Y | S |
| Macaca sylvanus | I | L | A | M | S | S | L | I | V | Y | S |
| Macropus robustus | I | L | S | L | S | G | L | S | V | Y | S |
| Mus musculus | I | L | A | T | S | S | L | S | V | Y | S |
| Nycticebus coucang | I | L | A | T | S | S | L | A | V | Y | S |
| Ornithorhynchus anatinus | V | L | S | V | S | G | L | S | V | Y | S |
| Oryctolagus cuniculus | I | L | A | T | S | S | L | A | V | Y | S |
| Ovis aries | M | L | A | M | S | S | L | A | V | Y | S |
| Pan paniscus | I | L | A | T | S | S | L | A | V | Y | S |
| Pan troglodytes | I | L | A | T | S | S | L | A | V | Y | S |
| Papio hamadryas | I | L | A | T | S | S | L | T | V | Y | S |
| Phoca vitulina | M | L | A | M | S | S | L | A | V | Y | S |
| Pongo abelii | I | L | A | A | S | S | L | T | V | Y | S |
| Pongo pygmaeus | I | L | A | T | S | S | L | T | V | Y | S |
| Rattus norvegicus | I | L | A | T | S | S | L | S | V | Y | S |
| Rhinoceros unicornis | M | L | A | M | S | S | L | A | V | Y | S |
| Sciurus vulgaris | I | L | A | T | S | S | L | A | V | Y | A |
| Sus scrofa | M | L | A | M | S | S | L | A | V | Y | S |
| Talpa europaea | M | L | A | V | S | S | L | A | V | Y | S |
| Tarsius bancanus | I | L | A | M | S | S | L | A | V | Y | S |
| Vicugna pacos | M | L | A | M | S | S | L | A | V | Y | S |
| Xenopus laevis | I | L | A | L | S | S | L | A | V | Y | T |